Seven patients discontinued the supplements consumption, three from placebo group and four from vitamin D group. An informed consent was obtained from all of the participants. The participants of this randomized double-blind placebo-controlled clinical trial study consist of 65 diabetic type 2 patients at the age range of 30–60 years old who agreed to take place in our study between September 2012 and February 2013. reported high prevalence of vitamin D deficiency in several cities of Iran ( 11).īecause of the role of vitamin D in insulin function and the prevalence of vitamin D deficiency in Iran, the aim of this study was to examine the effects of vitamin D supplementation on glucose control and insulin sensitivity and lipid profile in patients with type 2 diabetes. Vitamin D supplementation increases significantly insulin sensitivity in IGT patients ( 10). Lower circulating level of calcidiol was associated with the increased risk of coronary artery disease in diabetic patients ( 9). Therefore, the correction of vitamin D deficiency may result in improved glucose control and has beneficial effects on complications of diabetes type 2 ( 8). Vitamin D may also regulate glucose homeostasis by stimulating insulin release from pancreatic B-cells ( 6, 7).
Vitamin D may facilitate insulin function by regulating its receptor expression, so it may be increases insulin sensitivity ( 5).
There are several studies showing that vitamin D deficiency may resulted in developing diabetes type 2 ( 2– 4).
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